Dr. Falk Video-Report – interview with Prof. Evan Dellon, Chapel Hill (USA), which took place during ueg week 2019 in Barcelona (Spain) within the scope of the Satellite Symposium „EoE – Recent Developments in Diagnosis & Treatment“. In part II of the interview „Who gets EoE?“ Prof. Dellon describes genetic and geographical risk factors for the development of the disease.
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Who gets EoE? – Part II: Genetic & geographical risk factors
The most important facts summarized:
- Is there anything known about the interactions between genetic and environmental risk factors?
- A gene and environment interaction is very likely
- A number of gene variants, so-called SNPs (Single Nucleotide Polymorphisms), are associated with EoE. Examples are the SNPs in the Calpain-14-gene or TGF-β gene
- Do you have an explanation for the existence of geographical EoE-hotspots?
- The prevalence is quite similar in North America, western Europe, Australia and probably South America
- In the Middle East, Asia and Sub-Saharan Africa EoE is less common
- The presence in western countries like the US seems tob e associated with air pollution and large commercial farming enterprises
- It is assumed that environmental factors harm the esophageal barrier and thereby expose the esophagus to allergenic triggers
- The peak prevalence of EoE around the age of 35 to 50 could be associated with the increase in mass farming practices and changes in the food supply 30 to 50 years ago