Collagenous colitis – Example
Author: Prof. em. Dr. med. S. Liebe, University Hospital Rostock, Rostock, Germany
From: Falk Media Service D34, Endoscopy Practice on Video - Selected Diseases of the Colon
2. Edition 2012. © Falk Foundation e.V. All rights reserved.
This 89-year-old white female reported a six-week history of watery diarrhea. Because of her advanced age, the patient was scheduled for colonoscopy on an inpatient basis. The patient took no medication with the exception of NSAIDs for multiple joint complaints.
A follow-up colonoscopy was performed 11 days later. The deep mucosal defects had healed down to discrete, narrow ulcerations.
The clinical cardinal symptom of collagenous colitis is chronic or intermittent watery diarrhea. The diagnosis is made histologically since the mucosa appears normal at endoscopy. There are rarely any complications reported and a connection with the use of NSAIDs is seldom. In individual cases, there may be increased vulnerability of the mucosa upon distention of the bowel, as occurs, for example, during colonoscopy. This appears to have been the case with the present patient.
Bonderup OK, Hansen JB, Birket-Smith L, Vestergaard V, Teglbjærg PS, Fallingborg J. Budesonide treatment of collagenous colitis: a randomised, double blind, placebo controlled trial with morphometric analysis. Gut. 2003;52:248-51.
(see also Videoclip 1).